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It shows strong antimicrobial properties within the group of defensins against a broad spectrum of microbes, including bacteria and fungi [181]

Ji R-R, Donnelly CR, Nedergaard M

PLoS ONE 8:e84194

Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]